GRK  2062 "Molecular Principles of Synthetic Biology"

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Dr. Pierre Ronceray: Learning force fields from Brownian trajectories in biological systems


Dr. Pierre Ronceray (Princeton University): Learning force fields from Brownian trajectories in biological systems

Time and date: Monday, January 21, 2019 at 14:00 c.t
Place: Room A318 (Theresienstrasse 37, 80333 München)


From nanometer-scale proteins to micron-scale colloidal particles, particles in biological and soft matter systems undergo Brownian dynamics: their deterministic motion due to the forces competes with the random diffusion due to thermal noise. In the absence of forces, all trajectories lookalike: the key information characterizing the system's dynamics thus lies in its force field. However, reconstructing the force field by inspecting microscopy observations of the system's trajectory is a hard problem, for two reasons. First, there needs to be enough information about the force available in the trajectory: the effect of the force field becomes apparent only after a long enough observation time. Second, one needs a practical method to extract that information and reconstruct the force field, which is challenging for force fields with a spatial structure, in particular in the presence of measurement noise. Here we address these two problems for steady-state Brownian trajectories. We first give a quantitative meaning to the information contained in a trajectory, and show how it limits force inference. We then propose a practical procedure to optimally use this information to reconstruct the force field by decomposing it into moments. Using simple model stochastic processes, we demonstrate thatour method permits a quantitative evaluation of phase space forces and currents, circulation, and entropy production with a minimal amount of data.